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Multiple Choice

Using Biest 2 mg estriol per 0.2 mL to prepare 100 mL, how much estriol and estradiol should be weighed? Note: final conversion is 1.033.

The calculation hinges on scaling a fixed ratio from a small amount of Biest to a 100 mL final volume. Biest is typically used in an 80/20 ratio of estriol to estradiol by weight. So per 0.2 mL of Biest, you have: - Estriol: 2 mg × 80% = 1.6 mg - Estradiol: 2 mg × 20% = 0.4 mg To make 100 mL, multiply these amounts by the scale factor 100 / 0.2 = 500: - Estriol needed = 1.6 mg × 500 = 800 mg = 0.8 g - Estradiol needed = 0.4 mg × 500 = 200 mg = 0.2 g The note about a final conversion of 1.033 adjusts the estradiol figure for density considerations, giving: 0.2 g × 1.033 ≈ 0.2066 g → rounds to 0.21 g Thus you weigh about 0.8 g of estriol and 0.21 g of estradiol to prepare 100 mL.

The calculation hinges on scaling a fixed ratio from a small amount of Biest to a 100 mL final volume.

Biest is typically used in an 80/20 ratio of estriol to estradiol by weight. So per 0.2 mL of Biest, you have:

  • Estriol: 2 mg × 80% = 1.6 mg

  • Estradiol: 2 mg × 20% = 0.4 mg

To make 100 mL, multiply these amounts by the scale factor 100 / 0.2 = 500:

  • Estriol needed = 1.6 mg × 500 = 800 mg = 0.8 g

  • Estradiol needed = 0.4 mg × 500 = 200 mg = 0.2 g

The note about a final conversion of 1.033 adjusts the estradiol figure for density considerations, giving:

0.2 g × 1.033 ≈ 0.2066 g → rounds to 0.21 g

Thus you weigh about 0.8 g of estriol and 0.21 g of estradiol to prepare 100 mL.