Which statement about full-face respirators used in hazardous drug handling is correct?

• A. They provide eye protection only.
• B. They provide eye and face protection and must be used during deep cleaning of the C-PEC, in the event of a spill larger than the spill kit can contain, or when splashes can occur.
• C. They are required only for routine handling outside the C-PEC.
• D. They are unnecessary for spill cleanups.

Answer: (B)

Full-face respirators are used when there is a real risk of exposure to hazardous drugs through splashes or aerosols, providing both eye protection and a seal around the entire face to protect the respiratory tract. This is crucial during deep cleaning of the C-PEC, when residues can become airborne, during spills larger than what the spill kit can handle, or whenever splashes could occur. In these situations, protecting both eyes and breathing is essential because exposure can happen through inhalation or ocular contact, and standard eye protection alone would not prevent inhalation of hazardous drug aerosols. They are not required for routine handling outside the C-PEC, where less intensive protection is typically adequate, and they are not unnecessary for spill cleanups; the need for respiratory protection rises when the spill is large or splashes are anticipated.